Opportunity Information: Apply for PAR 19 262
The Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional), funding opportunity number PAR 19 262, is a National Institutes of Health (NIH) grant mechanism designed to help launch the early independent careers of clinical researchers. Its core purpose is to support the research activities of investigators who are transitioning into independence and building their own clinical research programs. What makes this opportunity stand out is that it is structured as a deliberate bridge between the NIH Intramural Research Program (research conducted inside NIH) and the broader extramural research community (research conducted at universities, hospitals, and other outside institutions). In practice, it is meant to give promising clinician-scientists a strong, well-supported runway to establish an independent research identity, generate impactful results, and then either continue within NIH or move into an external institution with continued NIH backing.
The program is organized into two connected phases. In the first phase, selected Lasker Scholars receive an appointment as a tenure-track investigator within the NIH Intramural Research Program for up to 5 to 7 years. During this intramural period, scholars operate as independent investigators, meaning they lead their own research direction and are provided with independent research budgets to pursue their work. This structure is intended to give scholars access to the distinctive resources of NIH intramural science, such as specialized clinical research infrastructure, collaborative scientific communities, and the ability to run ambitious projects that benefit from centralized federal research capabilities.
The second phase is essentially the “bridge” component that links intramural training and launching with longer-term independence in the broader research ecosystem. Scholars who successfully complete the intramural phase can receive up to 3 additional years of NIH support to continue their research at an extramural research facility, such as a university or academic medical center. Alternatively, the scholar may be considered to remain as an investigator within the NIH intramural program rather than transitioning out. This second phase is meant to reduce the risk and disruption often associated with moving institutions or shifting from an internal federal setting to an externally funded academic environment, while preserving research momentum and helping the investigator solidify their independent program.
The opportunity is listed as a discretionary grant under the U.S. Department of Health and Human Services, National Institutes of Health, and it is “clinical trial optional,” meaning proposed research may include a clinical trial but does not have to. The expected number of awards is about five, indicating a highly selective program. The notice lists an award ceiling of 0, which typically signals that a fixed maximum dollar cap is not being provided in the general listing and that budget details are governed by the program structure and NIH policies rather than a simple top-line cap.
Eligibility is broad at the institutional level and includes a wide range of potential applicant organizations, such as public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and various government entities (state, county, city/township, special districts), as well as eligible tribal governments and tribal organizations. Even with broad institutional eligibility language, the program’s intent is clearly focused on supporting individual early-career clinical researchers as they establish independent research careers, with the institutional applicant serving as the formal administrative home for the application and award mechanics.
Key administrative details from the listing include a creation date of May 1, 2019, and an original closing date of August 30, 2019, which reflects the initial application deadline for that particular announcement cycle. The program is associated with multiple CFDA numbers (including 93.113, 93.121, 93.172, 93.233, 93.242, 93.307, 93.361, 93.398, and several in the 93.8xx range), reflecting that multiple NIH Institutes and Centers may participate or that the program spans several NIH funding/mission areas connected to health and clinical research.
Overall, the Lasker Clinical Research Scholars Program is best understood as a prestige, high-support career acceleration pathway for independent clinical investigators, combining a substantial intramural tenure-track period at NIH with an optional, supported transition to an extramural institution. Its design aims to keep talented clinician-scientists doing ambitious, patient-oriented research by giving them time, resources, and continuity at the moment their careers typically face the steepest “independence gap.”Apply for PAR 19 262
- The Department of Health and Human Services, National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.233, 93.242, 93.307, 93.361, 93.398, 93.837, 93.838, 93.839, 93.840, 93.847, 93.853, 93.855, 93.865, 93.867.
- This funding opportunity was created on May 01, 2019.
- Applicants must submit their applications by Aug 30, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is the Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional)?
The Lasker Clinical Research Scholars Program is a National Institutes of Health (NIH) grant mechanism designed to launch the early independent careers of clinical researchers by supporting their research as they transition into independence and build their own clinical research programs.
What is the funding opportunity number for this program?
The funding opportunity number is PAR 19 262.
What is the main purpose of this opportunity?
The core purpose is to support research activities of early-career clinical investigators who are transitioning into independence, helping them establish an independent research identity, generate impactful results, and sustain momentum as they build their own clinical research programs.
What makes this program different from typical NIH opportunities?
It is structured as a deliberate bridge between the NIH Intramural Research Program (research conducted inside NIH) and the extramural research community (research conducted at universities, hospitals, and other outside institutions). The design provides a well-supported runway for independence within NIH, with an option for continued NIH support during a transition to an external institution.
How is the program structured?
The program has two connected phases: (1) an intramural phase as a tenure-track investigator in the NIH Intramural Research Program for up to 5 to 7 years, and (2) a potential bridge phase of up to 3 additional years of NIH support to continue research at an extramural research facility, such as a university or academic medical center, or the scholar may be considered to remain within NIH intramurally.
What happens during the first (intramural) phase?
Selected Lasker Scholars receive an appointment as a tenure-track investigator within the NIH Intramural Research Program for up to 5 to 7 years. During this period, scholars operate as independent investigators, leading their own research direction and receiving independent research budgets, while gaining access to NIH intramural resources and clinical research infrastructure.
How long is the intramural phase?
The intramural tenure-track investigator phase can last up to 5 to 7 years.
What kinds of resources are highlighted as part of the NIH intramural environment?
The listing emphasizes access to specialized clinical research infrastructure, collaborative scientific communities, and the ability to run ambitious projects supported by centralized federal research capabilities.
What is the second (bridge/extramural) phase?
After successfully completing the intramural phase, scholars can receive up to 3 additional years of NIH support to continue their research at an extramural research facility (for example, a university or academic medical center). This phase is intended to reduce disruption and risk when transitioning from an intramural NIH setting to an externally funded environment, while preserving research momentum.
How long can the extramural bridge support last?
Up to 3 additional years of NIH support may be available for research at an extramural institution.
Is leaving NIH required after the intramural phase?
No. The listing indicates that, as an alternative to transitioning to an extramural institution, the scholar may be considered to remain as an investigator within the NIH intramural program.
Is this opportunity clinical-trial focused?
It is labeled "clinical trial optional," meaning proposed research may include a clinical trial, but a clinical trial is not required.
What federal agency sponsors this opportunity?
The program is administered under the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH).
What type of award is this listed as?
It is listed as a discretionary grant.
How competitive is the program based on the expected number of awards?
The expected number of awards is about five, which suggests the program is highly selective.
Is there a maximum award amount (award ceiling) listed?
The notice lists an award ceiling of 0, which typically indicates that a fixed maximum dollar cap is not provided in the general listing and that budget details follow program structure and NIH policies rather than a single stated ceiling.
Who is eligible to apply at the institutional level?
Institutional eligibility is broad and includes public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and government entities (state, county, city/township, and special districts), as well as eligible tribal governments and tribal organizations.
If institutions are eligible, who is the program really intended to support?
Even with broad institutional eligibility language, the program intent is clearly focused on supporting individual early-career clinical researchers as they establish independent research careers. The institution serves as the formal administrative home for the application and award mechanics.
What is the relationship between the intramural and extramural research environments in this program?
The program is specifically designed to connect the NIH intramural environment (inside NIH) with the broader extramural research community (outside institutions like universities and hospitals) by offering a structured transition path with continued NIH support.
What are the key dates included in the listing?
The listing includes a creation date of May 1, 2019, and an original closing date of August 30, 2019, reflecting the initial application deadline for that particular announcement cycle.
What CFDA numbers are associated with this opportunity?
The program is associated with multiple CFDA numbers, including 93.113, 93.121, 93.172, 93.233, 93.242, 93.307, 93.361, 93.398, and several in the 93.8xx range. This suggests multiple NIH Institutes and Centers may participate or that the program spans several NIH mission areas connected to health and clinical research.
Where can the extramural phase take place?
The extramural phase can take place at an extramural research facility such as a university or academic medical center.
How does the program help with the "independence gap" in research careers?
Its design provides time, resources, and continuity at the moment when clinician-scientists often face the steepest transition challenges. The intramural tenure-track period supports independent work with NIH resources, and the optional extramural bridge reduces disruption by continuing NIH backing during a move to an external institution.
What is the overall goal for scholars by the end of the program?
The stated intent is to help promising clinician-scientists establish an independent research identity, produce impactful results, and either continue within NIH or transition to an extramural institution while maintaining research momentum with continued NIH support.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 19 262) also looked into and applied for these:
| Funding Opportunity |
|---|
| Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional) Apply for PAR 20 167 Funding Number: PAR 20 167 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Emergency Awards: RADx-rad Data Coordination Center (DCC) (U24 Clinical Trial Not Allowed) Apply for RFA OD 20 019 Funding Number: RFA OD 20 019 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $4,000,000 |
| Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp) Apply for PA 16 287 Funding Number: PA 16 287 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BD2K Research Education Curriculum Development: Data Science Overview for Biomedical Scientists (R25) Apply for RFA ES 16 011 Funding Number: RFA ES 16 011 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $100,000 |
| Big Data to Knowledge (BD2K) Enhancing the Efficiency and Effectiveness of Digital Curation for Biomedical Big Data (U01) Apply for RFA LM 17 001 Funding Number: RFA LM 17 001 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $350,000 |
| Support of Competitive Research (SCORE) Pilot Project Award (SC2) Apply for PAR 16 438 Funding Number: PAR 16 438 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $100,000 |
| BD2K Support for Meetings of Data Science Related Organizations (U13) Apply for RFA CA 16 020 Funding Number: RFA CA 16 020 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $470,000 |
| Administrative Supplement for Research on Sex/Gender Influences (Admin Supp) Apply for PA 17 078 Funding Number: PA 17 078 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research on the Health of Women of Underrepresented, Understudied and Underreported (U3) Populations An ORWH FY17 Administrative Supplement (Admin Supp) Apply for PA 17 101 Funding Number: PA 17 101 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Lasker Clinical Research Scholars Program Si2/R00 Apply for PAR 17 254 Funding Number: PAR 17 254 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2017-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]) Apply for PA 17 303 Funding Number: PA 17 303 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2017-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) Apply for PA 17 302 Funding Number: PA 17 302 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp) Apply for PA 18 314 Funding Number: PA 18 314 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) Apply for PA 18 403 Funding Number: PA 18 403 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Clinical Scientist Research Career Development Award (Parent K08 - No Independent Clinical Trials) Apply for PA 18 373 Funding Number: PA 18 373 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 - Independent Clinical Trials Not Allowed) Apply for PA 18 375 Funding Number: PA 18 375 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 - No Independent Clinical Trials) Apply for PA 18 396 Funding Number: PA 18 396 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Not Allowed) Apply for PA 18 398 Funding Number: PA 18 398 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) Apply for PA 18 484 Funding Number: PA 18 484 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Academic Research Enhancement Award (Parent R15 Clinical Trial Not Allowed) Apply for PA 18 504 Funding Number: PA 18 504 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $300,000 |
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