Opportunity Information: Apply for RFA AI 22 067
The National Institutes of Health (NIH) is soliciting applications for the International Centers of Excellence for Malaria Research (ICEMR) Program under Funding Opportunity Number RFA AI 22 067. This is a discretionary health research opportunity funded as a cooperative agreement (U19), meaning awardees should expect substantial scientific or programmatic involvement from NIH staff during the life of the project. The FOA is explicitly marked "Clinical Trial Not Allowed," so the supported work must be structured as research that does not meet NIH's definition of a clinical trial, even if it involves human data or samples (for example, observational studies or non-interventional research, depending on how the project is designed).
At its core, the ICEMR Program is meant to build and sustain a multidisciplinary, international network of research centers based in malaria-endemic settings. The research focus is twofold. First, centers are expected to deepen understanding of malaria pathogenesis, epidemiology, and transmission, which can include questions about how infections cause disease, how malaria spreads in real-world environments, and how patterns of risk change across seasons, geographies, and populations. Second, centers are expected to generate evidence that evaluates and optimizes interventions and informs the development of new tools and strategies aimed at malaria control, elimination, and eventual eradication. In practical terms, the program is designed to link basic, translational, and population-level research so that findings can directly shape the way malaria programs and future technologies are designed and used.
A defining feature of this FOA is where and how the work must be carried out. The supported research is intended to be conducted primarily in countries where malaria is endemic, and the application must demonstrate significant involvement of local and regional researchers in the study design, development, and execution. This is more than a general encouragement of collaboration; the program is structured to ensure that endemic-country investigators and institutions are integral partners with meaningful roles in leadership, scientific decision-making, and implementation. Proposals that rely heavily on external leadership without clear, substantive engagement and capacity integration in-country would be misaligned with the intent of the initiative.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; and other entities. The FOA also highlights additional eligible groups such as non-domestic (non-U.S.) entities (foreign organizations), regional organizations, U.S. territories or possessions, faith-based or community-based organizations, and multiple categories of minority-serving and tribal-serving institutions, including HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities. This wide eligibility reflects the program's goal of building strong, locally grounded consortia that can combine scientific depth with operational reach in endemic settings.
From the funding details provided, the award ceiling is listed as $800,000, and the CFDA (Assistance Listing) number is 93.855. The original application closing date was May 4, 2023, and the FOA record shows a creation date of November 22, 2022. As a cooperative agreement, applicants should plan for an active partnership model with NIH, where milestones, data sharing expectations, and coordination across the broader ICEMR network are often central to how the program operates. Overall, this opportunity is aimed at supporting well-integrated research centers that can produce actionable knowledge about malaria biology and transmission while strengthening research leadership and capability in the regions most affected by the disease.Apply for RFA AI 22 067
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "International Centers of Excellence for Malaria Research (U19 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on 2022-11-22.
- Applicants must submit their applications by 2023-05-04. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $800,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs) - NIH International Centers of Excellence for Malaria Research (ICEMR) Program (RFA AI 22 067)
What is this funding opportunity?
This opportunity is the National Institutes of Health (NIH) solicitation for applications to the International Centers of Excellence for Malaria Research (ICEMR) Program under Funding Opportunity Number (FON) RFA AI 22 067.
What type of award is NIH offering?
NIH is offering a cooperative agreement (U19). A cooperative agreement is different from a standard grant because NIH staff are expected to have substantial scientific or programmatic involvement during the project period.
What does it mean that this is a cooperative agreement (U19)?
It means awardees should expect an active partnership model with NIH. Based on the description provided, this can include NIH involvement related to milestones, expectations for data sharing, and coordination across the broader ICEMR network.
Are clinical trials allowed under this FOA?
No. The FOA is explicitly marked "Clinical Trial Not Allowed." Supported work must be structured so it does not meet NIH's definition of a clinical trial.
Can research still involve human data or human samples?
Yes, as long as the study is designed so it does not meet NIH's definition of a clinical trial. The description notes examples such as observational studies or other non-interventional research, depending on how the project is designed.
What is the main purpose of the ICEMR Program?
The ICEMR Program is intended to build and sustain a multidisciplinary, international network of research centers based in malaria-endemic settings. The centers are expected to generate knowledge that can directly shape malaria programs and future technologies.
What research topics are centers expected to address?
The research focus is described as twofold: (1) deepening understanding of malaria pathogenesis, epidemiology, and transmission; and (2) generating evidence that evaluates and optimizes interventions and informs the development of new tools and strategies for malaria control, elimination, and eventual eradication.
What does the FOA say about malaria pathogenesis, epidemiology, and transmission research?
The FOA emphasizes questions such as how infections cause disease, how malaria spreads in real-world environments, and how patterns of risk change across seasons, geographies, and populations.
What does the FOA mean by evaluating and optimizing interventions?
Based on the description provided, centers are expected to generate evidence that helps assess how interventions perform and how they can be improved, while also informing the development of new tools and strategies supporting malaria control and elimination.
Where is the research expected to be conducted?
The supported research is intended to be conducted primarily in countries where malaria is endemic.
How important is involvement from malaria-endemic country researchers and institutions?
It is a defining feature of this FOA. Applications must demonstrate significant involvement of local and regional researchers in study design, development, and execution, with meaningful roles in leadership, scientific decision-making, and implementation.
What kinds of proposals would be misaligned with the intent of the initiative?
The description indicates that proposals relying heavily on external leadership, without clear and substantive engagement and capacity integration in-country, would be misaligned with the intent of the program.
Who is eligible to apply?
Eligibility is broad and includes U.S. and non-U.S. organizations. Examples listed include various levels of government (state, county, city/township), special district governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, tribal governments and tribal organizations (including those not federally recognized), public housing authorities/Indian housing authorities, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses) and small businesses, and other entities.
Are foreign (non-U.S.) organizations eligible?
Yes. The FOA highlights non-domestic (non-U.S.) entities (foreign organizations) as eligible applicants.
Are regional organizations eligible?
Yes. Regional organizations are explicitly listed among additional eligible groups.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included in the listed eligible groups.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included among the additional eligible groups highlighted in the FOA.
Are minority-serving and tribal-serving institutions eligible?
Yes. The FOA highlights multiple categories of minority-serving and tribal-serving institutions as eligible, including HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities.
What is the maximum award amount listed?
The award ceiling is listed as $800,000.
What is the Assistance Listing (CFDA) number for this opportunity?
The CFDA (Assistance Listing) number provided is 93.855.
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA AI 22 067.
What were the key dates shown in the FOA record?
The FOA record shows a creation date of November 22, 2022, and the original application closing date was May 4, 2023.
What kind of program structure is NIH trying to build through ICEMR?
The program is described as a network of multidisciplinary international research centers. It is designed to link basic, translational, and population-level research so findings can inform malaria control programs and the development and use of future tools and strategies.
What should applicants expect regarding coordination across the ICEMR network?
Because this is a cooperative agreement and is described as a networked program, applicants should plan for coordination across the broader ICEMR network, along with expectations around milestones and data sharing as part of how the program operates.
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