Opportunity Information: Apply for RFA AI 17 010
The NIH funding opportunity titled "Dysregulation of Immune Cell Regulatory Pathways by Mtb in the Context of HIV Infection (R61/R33)" (Funding Opportunity Number RFA-AI-17-010) supports preclinical research focused on how Mycobacterium tuberculosis (Mtb) disrupts immune regulation when HIV infection is also present. The central scientific idea is that TB disease and TB/HIV co-infection are shaped not only by pathogen burden, but also by Mtb-driven interference with immune cell regulatory pathways that normally keep inflammation, pathogen killing, and tissue repair in balance. This FOA aims to push beyond descriptive immunology by encouraging studies that pinpoint specific pathway changes caused by Mtb in HIV-affected immune systems, then test practical ways to reverse or counteract those changes.
The research emphasis is on identifying Mtb-mediated alterations in key regulatory programs within immune cells in the setting of HIV, and then evaluating strategies that restore healthier immune function. The intended outcomes include improved treatment approaches for TB and TB/HIV co-infection, reduction of long-term tissue damage that can persist even after infection control, and the possibility of improving vaccine performance by correcting immune dysfunction that undermines protective responses. In other words, applicants are expected to connect mechanisms to interventions: clarify what regulatory circuits are being altered, show why those changes matter for disease progression or immune pathology, and provide preclinical evidence that targeted reversal can yield measurable benefits such as better control of infection, less immunopathology, or stronger vaccine-induced immunity.
The award mechanism is the R61/R33 phased innovation structure. In general terms, this format is designed for projects that begin with a high-impact, milestone-driven exploratory phase (R61) and then transition to a more advanced developmental/validation phase (R33) if early goals are met. This supports risk-tolerant ideas while still requiring clear go/no-go progress markers, which fits the FOA's focus on innovative preclinical work that should move toward actionable strategies rather than stopping at observation alone.
The opportunity falls under the NIH category of discretionary grant funding, within the health funding activity area, and is associated with CFDA numbers 93.855 and 93.856. The sponsoring agency is the National Institutes of Health. Key administrative details from the source include an original closing date of 2017-08-01 and a creation date of 2017-04-07. While the source text lists "AwardCeiling" and "ExpectedAwards," those fields are not populated in the provided data, so the summary cannot specify a maximum award amount or the anticipated number of awards based on this excerpt alone.
Eligibility is broad and includes many types of domestic U.S. organizations and governments, such as state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; and public housing authorities/Indian housing authorities. It also includes Native American tribal governments that are federally recognized, and Native American tribal organizations that are not federally recognized tribal governments. Nonprofit organizations are eligible whether or not they have 501(c)(3) status, as long as they are not institutions of higher education, and for-profit organizations are eligible as well (other than small businesses), alongside small businesses. The FOA also explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). It further allows eligible federal agencies, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, and non-domestic (non-U.S.) entities (foreign organizations), indicating an openness to international or multi-region collaborations where scientifically justified.
Taken together, this FOA targets the intersection of TB immunology, HIV-associated immune dysregulation, and translationally oriented preclinical intervention testing. Strong applications would be expected to define specific immune cell regulatory pathways impacted by Mtb during HIV infection, justify their relevance to TB/TB-HIV disease outcomes, and present a credible preclinical plan for testing reversal strategies that could eventually inform better therapeutics, improved management of inflammatory damage, or enhanced vaccine effectiveness.Apply for RFA AI 17 010
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Dysregulation of Immune Cell Regulatory Pathways by Mtb in the Context of HIV Infection (R61/R33)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855, 93.856.
- This funding opportunity was created on 2017-04-07.
- Applicants must submit their applications by 2017-08-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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