Opportunity Information: Apply for PAR 25 167
The Cancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required), funding opportunity number PAR 25-167, is a National Institutes of Health (NIH) grant run through the National Cancer Institute (NCI). Its purpose is to fund investigator-initiated clinical trials that can meaningfully reduce the overall burden of cancer by improving how cancer is prevented, detected early, and managed across the continuum of care. The program emphasizes research that can lead to real-world improvements in clinical practice and/or public health, rather than studies that are primarily exploratory without a clear path to impact.
The clinical focus is specifically on cancer prevention and control topics. Examples of the kinds of areas the NOFO is designed to support include early detection and screening approaches, prevention strategies (including interception, meaning intervening during early biological changes before invasive cancer develops), improvements in healthcare delivery related to cancer, and interventions that enhance quality of life and survivorship outcomes. The intended scope aligns with the interests of the NCI Division of Cancer Prevention and the NCI Division of Cancer Control and Population Sciences, signaling that projects should fit within prevention, population science, implementation, behavioral, outcomes, and care delivery domains tied to cancer.
A key requirement is that applications must propose a study that meets the NIH definition of a clinical trial and must include the specific clinical trial information required by the funding announcement. In other words, this is not an optional clinical trial mechanism; the project is expected to be a true clinical trial as NIH defines it, with appropriate trial-specific details provided in the application.
At the same time, the NOFO is explicit about what it will not support: it does not fund clinical trials focused on cancer diagnosis and/or oncologic therapy in patients. That exclusion is important because it differentiates this program from treatment-oriented trial funding. Applicants proposing trials of therapeutic regimens, treatment combinations, or other oncology treatment studies in patients would fall outside the allowable scope for this opportunity.
The funding instrument is an NIH R01 research project grant, categorized as a discretionary grant, and it falls under the Education and Health activity category. The associated CFDA numbers listed are 93.393 and 93.399. The opportunity was created on 2024-11-12, and the original closing date provided is 2027-01-07. An award ceiling and expected number of awards are not specified in the supplied source data.
Eligibility is broad and includes many types of domestic organizations and some non-domestic entities. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts, as well as public and state-controlled institutions of higher education and private institutions of higher education. Tribal eligibility includes Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments), along with Indian housing authorities. Nonprofit organizations may apply whether or not they have 501(c)(3) status (so long as they are not institutions of higher education under that category), and for-profit organizations are also eligible (other than small businesses, with small businesses separately listed as eligible). The NOFO also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. (foreign) organizations.
Overall, this opportunity is best suited for investigators ready to run a well-defined clinical trial aimed at preventing cancer, improving screening/early detection, strengthening cancer-related healthcare delivery, or improving survivorship and quality of life outcomes, with a clear rationale for how the results could change practice or improve population health, while staying away from trials centered on diagnostic workups or cancer treatment in patients.Apply for PAR 25 167
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Cancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.399.
- This funding opportunity was created on 2024-11-12.
- Applicants must submit their applications by 2027-01-07.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
This opportunity is the Cancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required).
What is the funding opportunity number?
The funding opportunity number is PAR 25-167.
Which agency is offering this grant?
The grant is offered by the National Institutes of Health (NIH) through the National Cancer Institute (NCI).
What is the main purpose of this program?
The purpose is to fund investigator-initiated clinical trials that can meaningfully reduce the overall burden of cancer by improving how cancer is prevented, detected early, and managed across the continuum of care.
What kind of impact does the program emphasize?
The program emphasizes research that can lead to real-world improvements in clinical practice and/or public health, rather than studies that are primarily exploratory without a clear path to impact.
What type of award mechanism is used?
The funding instrument is an NIH R01 research project grant (a discretionary grant).
Is a clinical trial required under this opportunity?
Yes. Applications must propose a study that meets the NIH definition of a clinical trial, and the application must include the clinical trial-specific information required by the funding announcement.
Can an application be submitted without a clinical trial (for example, as an observational or exploratory study)?
No. This opportunity is explicitly "Clinical Trial Required," meaning the proposed project is expected to be a true NIH-defined clinical trial with appropriate trial-specific details included.
What research areas are in scope for this NOFO?
The clinical focus is cancer prevention and control. Examples mentioned include early detection and screening approaches, prevention strategies (including interception), improvements in healthcare delivery related to cancer, and interventions that enhance quality of life and survivorship outcomes.
What does "interception" mean in the context of this program?
Interception is described as intervening during early biological changes before invasive cancer develops.
What does "across the continuum of care" mean here?
It refers to improving cancer-related outcomes across prevention, early detection, healthcare delivery, survivorship, and quality of life, rather than focusing only on one narrow point of care.
Which parts of NCI does the scope align with?
The scope aligns with the interests of the NCI Division of Cancer Prevention and the NCI Division of Cancer Control and Population Sciences.
What types of scientific domains does NCI signal interest in for this program?
Projects should fit within prevention, population science, implementation, behavioral, outcomes, and care delivery domains tied to cancer.
What kinds of studies are explicitly not supported?
The NOFO does not fund clinical trials focused on cancer diagnosis and/or oncologic therapy in patients.
Does this program support clinical trials of cancer treatment regimens?
No. Trials of therapeutic regimens, treatment combinations, or other oncology treatment studies in patients are outside the allowable scope for this opportunity.
Does the exclusion of "cancer diagnosis" mean any diagnostic-related work is not allowed?
The information provided states the program does not fund clinical trials focused on cancer diagnosis. The intended focus is prevention and control topics such as early detection and screening, prevention strategies, healthcare delivery improvements, and survivorship/quality-of-life interventions.
Who is this opportunity best suited for?
It is best suited for investigators ready to run a well-defined clinical trial aimed at preventing cancer, improving screening/early detection, strengthening cancer-related healthcare delivery, or improving survivorship and quality of life outcomes, with a clear rationale for how results could change practice or improve population health.
What is the activity category listed for this opportunity?
The activity category is Education and Health.
What CFDA numbers are associated with this grant?
The associated CFDA numbers listed are 93.393 and 93.399.
When was this opportunity created?
The opportunity was created on 2024-11-12.
What is the closing date for this opportunity?
The original closing date provided is 2027-01-07.
Is an award ceiling listed?
No award ceiling is specified in the supplied source data.
Is the expected number of awards listed?
No expected number of awards is specified in the supplied source data.
What types of organizations are eligible to apply?
Eligibility is broad and includes many types of domestic organizations and some non-domestic entities, including governments, higher education institutions, nonprofits, for-profits, small businesses, tribal entities, certain serving institutions, faith-based/community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. (foreign) organizations.
Are state and local governments eligible?
Yes. Eligible applicants include state governments, county governments, city or township governments, special district governments, and independent school districts.
Are institutions of higher education eligible?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are eligible.
Are tribal governments and tribal organizations eligible?
Yes. Eligible applicants include Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments). Indian housing authorities are also listed as eligible.
Are nonprofit organizations eligible, and is 501(c)(3) status required?
Nonprofit organizations may apply whether or not they have 501(c)(3) status (as long as they are not institutions of higher education under that category, as described in the provided information).
Are for-profit organizations eligible?
Yes. For-profit organizations are eligible, and small businesses are also separately listed as eligible.
Are small businesses eligible?
Yes. Small businesses are listed as eligible applicant types.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are highlighted among eligible applicant types.
Are minority-serving institutions included in the eligibility list?
Yes. The NOFO highlights Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed among eligible applicant types.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. Non-U.S. (foreign) organizations are listed as eligible.
Are federal agencies eligible applicants?
Yes. Eligible federal agencies are listed among the eligible applicant types.
Does the program require projects to match NCI prevention and control priorities?
Yes. The described scope and examples indicate projects should fit within cancer prevention and control topics aligned with NCI prevention and cancer control/population sciences interests.
What should applicants be careful to avoid when designing a trial for this program?
Applicants should avoid proposing clinical trials centered on cancer diagnosis workups and/or oncologic therapy in patients, including therapeutic regimens or treatment combinations, because those are explicitly excluded.
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| Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed) Apply for PAR 25 255 Funding Number: PAR 25 255 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Pragmatic Trials across the Cancer Control Continuum (UG3/UH3 Clinical Trial Required) Apply for PAR 25 072 Funding Number: PAR 25 072 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Impacts of climate change across the cancer control continuum (R01 Clinical Trial Optional) Apply for PAR 25 094 Funding Number: PAR 25 094 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Mentored Research Scientist Development Award to Promote Diversity (K01 Independent Clinical Trial Not Allowed) Apply for PAR 24 316 Funding Number: PAR 24 316 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Impacts of climate change across the cancer control continuum (R21 Clinical Trial Optional) Apply for PAR 25 152 Funding Number: PAR 25 152 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Basic Research in Cancer Health Disparities (R21 Clinical Trial Not Allowed) Apply for PAR 25 244 Funding Number: PAR 25 244 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Basic Research in Cancer Health Disparities (R01 Clinical Trial Not Allowed) Apply for PAR 25 243 Funding Number: PAR 25 243 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Investigator Initiated Innovation in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed) Apply for PAR 25 228 Funding Number: PAR 25 228 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed) Apply for PAR 25 096 Funding Number: PAR 25 096 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed) Apply for PAR 25 095 Funding Number: PAR 25 095 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| NCMRR Early Career Research Award (R03 Clinical Trial Optional) Apply for PAR 25 124 Funding Number: PAR 25 124 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R21 Clinical Trial Not Allowed) Apply for PAR 25 070 Funding Number: PAR 25 070 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional) Apply for PAR 25 069 Funding Number: PAR 25 069 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advancing Genomic Medicine Research (R21 Clinical Trial Optional) Apply for RFA HG 25 003 Funding Number: RFA HG 25 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
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